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Tesamorelin, a synthetic peptide analogue of GHRH. It is most commonly utilized for the treatment of HIV-related lipodystrophy, a condition that causes those affected to have an abnormal distribution of body fat. Tesamorelin enables patients to shed visceral adipose tissue, or fat around their organs, by increasing the production and release of growth hormone from the pituitary gland. https://peptide-works.com/tesamorelin/.
Researchers are scrutinizing how it impacts age-related disease, like cognitive function and metabolic health. Both endocrinology and metabolic research are intrigued by it, in light of its ability to affect body composition, and enhance insulin sensitivity.
Peptide Sequence (IUPAC Condensed): trans-hexenoyl-acid-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn- Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-LeuGln-Asp-Ile-Met-Ser-Arg-Gln- Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2
Molecular Formula: C221H366N72O67S
Molecular Weight: 5136 g/mol
Synonyms: (3E)-Hex-3-enoylsomatoliberin
View the Tesamorelin Certificate Of Analysis (COA)
View the Tesamorelin High Performance Liquid Chromatography (HPLC)


Tesamorelin acts by sending a signal to the pituitary gland to increase your body's own output of growth hormone (GH). Upon binding to GHRH receptors, it increase GH levels and subsequently IGF-1. These chemicals produce a process of fat burning (lipolysis) that is preferentially directed at visceral adipose tissue, another way it helps improve body composition. This is particularly Useful in such conditions such as HIV-related lipodystrophy.
Tesamorelin induces production of naturally occurring GH and is a safe alternative to directly administering GH. This minimizes the side effects sometimes seen with exogenous GH. Research also indicates that it may provide other benefits, such as improved insulin sensitivity, healthier cholesterol levels and possible protection for brain health. The presence of these factors makes Tesamorelin an attractive candidate for treatment.
Buy Tesamorelin Peptide Vial at Peptide Works. This lyophilizate is more than 99% pure. It is sold in vials of 2mg and 5mg, as well as a kit which comes with bacteriostatic water for reconstitution, syringes.
VAT reduction: Studies have demonstrated that Tesamorelin reduces VAT by 15%-20% in 6-12 months in ARTAb+ patients.
In patients who achieved ⩾8% VAT reduction in clinical trials, there were significant metabolic benefits with respect to the improved triglyceride and adiponectin levels as well as glucose homeostasis. These effects were maintained in cycle over 52 weeks, emphasizing the unique capacity of tesamorelin to decrease detrimental abdominal fat and enhance endocrine and metabolic profile in central fat mass patients.
Better Lipids: Studies show that tesamorelin provides better lipids by lowering the patients' VAT volume and waxing the fat quality. In HIV patients with central obesity, tesamorelin reduced VAT by 15.2%, thereby decreasing cardiovascular risk.
It also raise VAT and subcutaneous fat density (measured in Hounsfield Units), meaning smaller, healthier fat cells. This combined effect of decreasing the unhealthy fat content and enhancing the large amount of remaining (healthy) fat, together with improvements in triglyceride levels (−50 mg/dL) and cholesterol ratios demonstrates that tesamorelin has a very strong potential value for maintaining metabolic health in patients suffering from centralised fat deposition.
Improved Glucose Management:Tesamorelin has a neutral effect on glucose tolerance with metabolic gains [4]. Tesamorelin did not change insulin sensitivity, fasting glucose, HbA1c or overall diabetes control in 12‐week studies with patients diagnosed with type 2 diabetes.
Nevertheless, it decreased total cholesterol and non-HDL-cholesterol concentrations, explaining its beneficial effect on lipid metabolism. Conclusion: These data indicate that tesamorelin can improve metabolic health without loss of glycemic control, even with diabetic subjects.
Body composition improvements: clinical research from the literature indicates that Tesamorelin improves body composition by decreasing VAT, while also increasing muscle mass and quality. Among individuals with HIV and abdominal obesity, tesamorelin decreased VAT by 15%-20% in a time frame of 26-52 weeks whilst restoring the subcutaneous fat tissue.
It also enhanced the density and area of skeletal muscle in particular, that of the rectus and psoas muscles contributing to better quality of muscle. These improvements, in conjunction with favorable changes in body image and lipids, underscore tesamorelin as a potential modulator of metabolic and physical health.
Potential Benefit in NAFLD/NASH: It has also been shown that Tesamorelin can significantly reduce liver fat and improve markers of non-alcoholic fatty liver disease (NAFLD). In individuals with HIV and abdominal obesity tesamorelin resulted in a 37% decrease in hepatic fat fraction (HFF) over the course of 12 months, while 35% achieved normal HFF levels (<5%).
It also reduced ALT and AST in patients with increased baseline values, especially those who had extensive VAT reduction. These results indicate that tesamorelin may be a potential therapeutic option for NAFLD in HIV patients [9].
Potential Cognitive Effects: Tesamorelin research has demonstrated that the substance may have cognitive benefits due to an elevation of IGF-1 levels (which are important for brain function). Among HIV+ patients with abdominal obesity, tesamorelin produced a small decrease in waist circumference and trend toward improved neurocognitive function over 6 months but overall effects were not significant. IGF-1 and growth hormone pathways are associated with brain function in general, so tesamorelin has potential to reduce neurocognitive impairment although longer term cognitive effects should be confirmed.
Purchase Tesamorelin Pre Mixed Australia from Peptide Works. The pre-mixed pen kit contains 2mg cartridges, complete with cartridge pen, needle tips and carry case for convenient and precision use.
Some simple Q&A about Tesamorelin.
Buy Tesamorelin Nasal Spray from Peptide Works. Available in 15ml and 30ml glass vials, this nasal spray offers a simple needle-free route to effective delivery.
Could Tesamorelin Hold Promise for Body Composition in HIV?
Indirectly Acting Antiobesity Drugs Tesamorelin The effects of tesamorelin on the body composition in HIV involves a reduction in visceral fat as well as an increase in lean tissue mass. It works by promoting the release of growth hormone, which can help to regulate weight that has gotten out of control when it comes to fat and muscle. Clinical studies demonstrate a reduction in deep abdominal fat and an increase in lean muscle density with regular use. Tesamorelin is used to treat excess fat around the abdomen in HIV-positive patients who have undergone treatment.
Is There Anything Else Tesamorelin can Be Stacked with for Increased Results?
Tesamorelin can also be researched alongside other peptides such as Ipamorelin, CJC-1295 or Sermorelin in considering synergistic effects to growth hormone pathways. The peptides work via various pathways, which means researchers can study synergistic effects on metabolism and recovery markers. These peptide mixes are sold for research use only and are not meant for human or animal use.
What are the Risks of Tesamorelin?
Studies have found Tesamorelin may result in mild side effects. Typical side effects are redness, swelling or itching at the injection point. A small bit of research suggests short-term joint or muscle pain and mild fluid buildup. A couple of studies found slight changes in blood sugar, but they were lenient. In rare cases tingling or numbness are present. With adequate surveillance during research, it can be possible to keep a handle on these effects.
Is it legal to purchase Tesamorelin?
In the United States, Tesamorelin is only approved by the FDA for a defined medical purpose, but it is available for purchase online as research-grade at affordable prices to be used in laboratory studies. It is made available to research professionals and institutions, not for personal or medical use. Laws and regulations concerning research peptides differ for each state, we suggest you review your local laws regarding the use of research peptides before you purchase or use our compounds.

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